Literature summary for 3.2.2.22 extracted from

Bharadwaj, S.; Rathore, S.S.; Ghosh, P.C.
Enhancement of the cytotoxicity of liposomal ricin by the carboxylic ionophore monensin and the lysosomotropic amine NH4Cl in Chinese hamster ovary cells (2006), Int. J. Toxicol., 25, 349-359.

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Application

Application	Comment	Organism
medicine	following encapsulation in negatively charged liposomes, the cytotoxicity of ricin in chinese hamster ovary cells is markedly reduced. Lactose has no effect on the binding, internalization, and cytotoxicity of liposomal ricin. Both monensin and NH4Cl markedly enhance the cytotoxicity of liposomal ricin. The extent of exocytosis of free ricin is much higher as compared to liposomal ricin	Ricinus communis

Organism

Organism	UniProt	Comment	Textmining
Ricinus communis	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)