Literature summary for 3.2.2.22 extracted from

Nimmanapalli, R.; Lyu, M.A.; Du, M.; Keating, M.J.; Rosenblum, M.G.; Gandhi, V.
The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells (2007), Blood, 109, 2557-2564.

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Application

Application	Comment	Organism
medicine	construct of recombinant gelonin fused to cytokine B lymphocyte stimulator to specifically target quiescent B-CLL lymphocytes. The construct specifically binds and internalizes through cell-surface receptor BAFF-R into CD19 B-CLL lymphocytes and induces apoptosis at nanomolar concentrations. In contrast, rGel alone is not able to internalize into these leukemic lymphocytes. Mechanistically, the construct inhibits protein synthesis with an IC50 of less than 3 nM compared with more than 5000 nM for rGel toxin alone	Suregada multiflora

Protein Variants

Protein Variants	Comment	Organism
additional information	construct of recombinant gelonin fused to cytokine B lymphocyte stimulator to specifically target quiescent B-CLL lymphocytes. The construct specifically binds and internalizes through cell-surface receptor BAFF-R into CD19 B-CLL lymphocytes and induces apoptosis at nanomolar concentrations. In contrast, rGel alone is not able to internalize into these leukemic lymphocytes. Mechanistically, the construct inhibits protein synthesis with an IC50 of less than 3 nM compared with more than 5000 nM for rGel toxin alone	Suregada multiflora

Organism

Organism	UniProt	Comment	Textmining
Suregada multiflora	-	-	-

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Release 2023.1 (January 2023)