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Literature summary for 3.2.2.21 extracted from
- The Escherichia coli 3-methyladenine DNA glycosylase AlkA has a remarkably versatile active site (2004), J. Biol. Chem., 279, 26876-26884.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | the enzyme is induced in response to DNA alkylation, and it protects cells from alkylated nucleobases by catalyzing their excision | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alkylated DNA + H2O | AlkA has significant glycosylase activity towards each of the normal bases in DNA. AlkA binds nonspecifically to DNA and neither mismatches nor 7-methylguanine lesions are specifically recognized in the ground state | Escherichia coli | 3-methyladenine + 3-methylguanine + 7-methylguanine + 7-methyladenine + ? | - |
? | |
| additional information | the enzyme is induced in response to DNA alkylation, and it protects cells from alkylated nucleobases by catalyzing their excision | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-methyladenine DNA glycosylase II | - |
Escherichia coli |
| AlkA | - |
Escherichia coli |
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