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Literature summary for 3.2.2.21 extracted from

  • Terato, H.; Masaoka, A.; Asagoshi, K.; Honsho, A.; Ohyama, Y.; Suzuki, T.; Yamada, M.; Makino, K.; Yamamoto, K.; Ide, H.
    Novel repair activities of AlkA (3-methyladenine DNA glycosylase II) and endonuclease VIII for xanthine and oxanine, guanine lesions induced by nitric oxide and nitrous acid (2002), Nucleic Acids Res., 30, 4975-4984.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.21

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000031
-
 alkylated DNA, treated with N-methyl-N'-nitro-N-nitrosoguanidine pH 7.5, 37°C, excision of 7-methylguanine Escherichia coli
0.000053
-
 alkylated DNA, treated with N-methyl-N'-nitro-N-nitrosoguanidine pH 7.5, 37°C, excision of xanthine Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Escherichia coli
-
 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O Escherichia coli MV1161
-
 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 MV1161
-
Escherichia coli MV1161
-
 MV1161
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
 Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O
-
 Escherichia coli MV1161 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA, treated with N-methyl-N'-nitro-N-nitrosoguanidine + H2O
-
 Escherichia coli ?
-
 ?
alkylated DNA, treated with N-methyl-N'-nitro-N-nitrosoguanidine + H2O
-
 Escherichia coli MV1161 ?
-
 ?
additional information also capable to relase xanthine and oxanine, guanine lesions induced by nitrosation Escherichia coli ?
-
 ?
additional information also capable to relase xanthine and oxanine, guanine lesions induced by nitrosation Escherichia coli MV1161 ?
-
 ?