Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | prior complex formation between mismatch repair protein MutS and a heteroduplex containing an 5-formyluracil-guanine mispair inhibits the activity of AlkA to 5-formyluracil | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | Escherichia coli | DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | Escherichia coli AB1157 | DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
AB1157 | - |
Escherichia coli AB1157 | - |
AB1157 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | - |
Escherichia coli | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage | Escherichia coli | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | - |
Escherichia coli AB1157 | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage | Escherichia coli AB1157 | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
additional information | repairs 5-formyluracil, a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation, 5-hydroxymethyluracil, another major thymine methyl oxidation product, is not a substrate | Escherichia coli | ? | - |
? | |
additional information | repairs 5-formyluracil, a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation, 5-hydroxymethyluracil, another major thymine methyl oxidation product, is not a substrate | Escherichia coli AB1157 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AlkA protein | - |
Escherichia coli |