KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000021 | - |
alkylated DNA | pH 8.0, 37°C, excision of 5-formyluracil | Escherichia coli | |
0.00003 | - |
alkylated DNA | pH 8.0, 37°C, excision of 7-methylguanine | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | Escherichia coli | inducible pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | Escherichia coli MV1161 | inducible pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
MV1161 | - |
Escherichia coli MV1161 | - |
MV1161 | - |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | - |
Escherichia coli | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | inducible pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine | Escherichia coli | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | - |
Escherichia coli MV1161 | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
alkylated DNA + H2O | inducible pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine | Escherichia coli MV1161 | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
additional information | repairs 5-formyluracil, a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation, 5-hydroxymethyluracil, another major thymine methyl oxidation product, is not a substrate | Escherichia coli | ? | - |
? | |
additional information | repairs 5-formyluracil, a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation, 5-hydroxymethyluracil, another major thymine methyl oxidation product, is not a substrate | Escherichia coli MV1161 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AlkA protein | - |
Escherichia coli |