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Literature summary for 3.2.2.21 extracted from

  • Je, K.H.; Son, J.K.; O'Connor, T.R.; Lee, C.S.
    Hepsulfam induced DNA adducts and its excision repair by bacterial and mammalian 3-methyladenine DNA glycosylases (1998), Mol. Cells, 8, 691-697.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
-
Homo sapiens
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Escherichia coli
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Homo sapiens
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O Rattus norvegicus
-
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
human
-
Rattus norvegicus
-
rat
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein, purified from Escherichia coli Homo sapiens
recombinant protein, purified from Escherichia coli Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Homo sapiens 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
alkylated DNA + H2O
-
Rattus norvegicus 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
?
additional information excises N7 guanine adducts completely, also capable of removing normal base residues from DNA Escherichia coli ?
-
?
additional information fails to excise N7 guanine adducts Homo sapiens ?
-
?
additional information fails to excise N7 guanine adducts Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
AlkA protein
-
Escherichia coli