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Literature summary for 3.2.2.21 extracted from

  • Borys, E.; Kusmierek, J.T.
    Endogenous and exogenous DNA lesions recognized by N-alkylpurine-DNA glycosylases (1998), Acta Biochim. Pol., 45, 579-586.
    View publication on PubMed
Search for more literature for 3.2.2.21

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Escherichia coli
-
 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O Escherichia coli JM105
-
 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 JM105
-
Escherichia coli JM105
-
 JM105
-

Purification (Commentary)

Purification (Comment) Organism
purified from strain JM105 harboring pAlk10 plasmid Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
 Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O
-
 Escherichia coli JM105 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
additional information enzyme cleaves pBR322 and pAlk10 plasmids, excises adducts formed by chloroacetaldehyde, acrolein and croton aldehyde but is not able to excise malionaldehyde and bulky p-benzochinone adducts Escherichia coli ?
-
 ?
additional information enzyme cleaves pBR322 and pAlk10 plasmids, excises adducts formed by chloroacetaldehyde, acrolein and croton aldehyde but is not able to excise malionaldehyde and bulky p-benzochinone adducts Escherichia coli JM105 ?
-
 ?

Synonyms

Synonyms Comment Organism
ALK
-
 Escherichia coli
AlkA protein
-
 Escherichia coli