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Literature summary for 3.2.2.17 extracted from
- The reaction mechanism of DNA glycosylase/AP lyases at abasic sites (2001), Biochemistry, 40, 561-568.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NaBH4 | The rate of the covalent imine intermediate suggest that the reduction of the intermediate is rate-limiting in the reaction | Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, pH 6.8, for several days with no loss of activity | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 16-mers oligodeoxynucleotide + H2O | anomers of methyl-deoxyribofuranose analogues indicates that T4-pdg preferentially cleaved the beta-anomers | Escherichia coli | ? | - |
? | |
| DNA + H2O | the combined rate of sugar ring opening and reduction of the sugar is significantly slower than the rate of formation of (T4-pdg)-DNA intermediate | Escherichia coli | ? | - |
? | |
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Release 2023.1 (January 2023)
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