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Literature summary for 3.2.2.16 extracted from

  • Gutierrez, J.A.; Luo, M.; Singh, V.; Li, L.; Brown, R.L.; Norris, G.E.; Evans, G.B.; Furneaux, R.H.; Tyler, P.C.; Painter, G.F.; Lenz, D.H.; Schramm, V.L.
    Picomolar inhibitors as transition-state probes of 5-methylthioadenosine nucleosidases (2007), ACS Chem. Biol., 2, 725-734.
    View publication on PubMed
Search for more literature for 3.2.2.16

Inhibitors

Inhibitors Comment Organism Structure
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
4-chlorophenylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
benzylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
ethylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Streptococcus pneumoniae and human enzyme Escherichia coli
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Helicobacter pylori
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae and human enzyme Neisseria meningitidis
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Escherichia coli, Streptococcus pneumoniae and human enzyme Staphylococcus aureus
methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin-A analysis of Kd value, comparison with inhibition of Neisseria meningitides, Helicobacter pylori, Staphylococcus aureus, Escherichia coli and human enzyme Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Helicobacter pylori
-
-
-
Neisseria meningitidis
-
-
-
Staphylococcus aureus
-
-
-
Streptococcus pneumoniae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine early dissociative transition state Staphylococcus aureus
a
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine early dissociative transition state Neisseria meningitidis
a
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine early dissociative transition state Helicobacter pylori
a
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine late dissociative transition state Escherichia coli
a
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine late dissociative transition state Streptococcus pneumoniae
a