Literature summary for 3.2.2.1 extracted from

Chen, N.; Ge, H.; Xu, J.; Cao, Z.; Wu, R.
Loop motion and base release in purine-specific nucleoside hydrolase: a molecular dynamics study (2013), Biochim. Biophys. Acta, 1834, 1117-1124.

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Organism

Organism	UniProt	Comment	Textmining
Trypanosoma vivax	-	-	-

Synonyms

Synonyms	Comment	Organism
IAG-NH	-	Trypanosoma vivax
purine-specific inosine-adenosine-guanosine nucleoside hydrolase	-	Trypanosoma vivax
purine-specific nucleoside hydrolase	-	Trypanosoma vivax

General Information

General Information	Comment	Organism
additional information	regulation mechanisms of key residues and loops 1 and 2 for the base release, molecular dynamics simulations, overview. The base release process is not the rate-limiting step in the entire hydrolysis process, and the very low barrier of about 5.6 kcal/mol can bewashed out easily by the notable exothermicity fromthe substrate hydrolysis step. Glu82/Trp83 in loop 1 and His247/Arg252 in loop 2 are important to modulate the base release. Partial helix-to-coil change of loop 2 occurs along with the base release process	Trypanosoma vivax

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Release 2023.1 (January 2023)