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Literature summary for 3.2.2.1 extracted from

  • Goeminne, A.; McNaughton, M.; Bal, G.; Surpateanu, G.; Van Der Veken, P.; De Prol, S.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
    Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors (2008), Eur. J. Med. Chem., 43, 315-326.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1S)-1,4-dideoxy-1-(2-guanidinoethyl)-1,4-imino-D-ribitol
-
Trypanosoma vivax
1,4-dideoxy-(3-guanidinopropyl)-1,4-imino-D-ribitol
-
Trypanosoma vivax
1,4-dideoxy-1,4-imino-D-ribitol
-
Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-amidinobenzyl)-D-ribitol
-
Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-guanidinobenzyl)-D-ribitol
-
Trypanosoma vivax
1-guanidino-2,5-anhydro-1-deoxy-D-allitol
-
Trypanosoma vivax
1-guanidino-3,6-anhydro-1,2-dideoxy-D-allo-heptitol
-
Trypanosoma vivax
N-benzyl-1,4-dideoxy-1,4-imino-D-ribitol
-
Trypanosoma vivax

Organism

Organism UniProt Comment Textmining
Trypanosoma vivax
-
isoform IAG-NH
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-ribofuranoside + H2O
-
Trypanosoma vivax 4-nitrophenol + D-ribose
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0061
-
1,4-dideoxy-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
0.0067
-
1,4-dideoxy-1,4-imino-N-(4-amidinobenzyl)-D-ribitol pH 7.0, 35°C Trypanosoma vivax
0.007
-
1,4-dideoxy-1,4-imino-N-(4-guanidinobenzyl)-D-ribitol pH 7.0, 35°C Trypanosoma vivax
0.018
-
(1S )-1,4-dideoxy-1-(2-guanidinoethyl)-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
0.04
-
1,4-dideoxy-(3-guanidinopropyl)-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
0.059
-
N-benzyl-1,4-dideoxy-1,4-imino-D-ribitol pH 7.0, 35°C Trypanosoma vivax
0.309
-
1-guanidino-3,6-anhydro-1,2-dideoxy-D-allo-heptitol pH 7.0, 35°C Trypanosoma vivax
0.545
-
1-guanidino-2,5-anhydro-1-deoxy-D-allitol pH 7.0, 35°C Trypanosoma vivax