Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CuCl2 | strong noncompetitive inhibitor for enzyme from healthy individuals and mucopolysaccharidosis type I patients | Homo sapiens | |
EDTA | competitive, equal inhibition of enzyme from healthy individuals and mucopolysaccharidosis type I patients | Homo sapiens | |
NaCl | healthy individuals and 40% of heterocygotic mucopolysaccharidosis type I patients, activating for 60% of heterocygotic mucopolysaccharidosis type I patients | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.21 | - |
4-methylumbelliferyl-alpha-L-iduronide | pH 2.8, 37°C, enzyme from healthy individuals in the presence of 10 mM CuCl2l | Homo sapiens | |
0.22 | - |
4-methylumbelliferyl-alpha-L-iduronide | pH 2.8, 37°C, enzyme from healthy individuals | Homo sapiens | |
0.48 | - |
4-methylumbelliferyl-alpha-L-iduronide | pH 2.8, 37°C, enzyme from healthy individuals in the presence of 20 mM EDTA | Homo sapiens | |
0.81 | - |
4-methylumbelliferyl-alpha-L-iduronide | pH 2.8, 37°C, enzyme from healthy individuals in the presence of 0.1 M NaCl | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | involved in the degradation of dermatan sulfate and heparan sulfate, deficiency in alpha-L-iduronidase causes mucopolysaccharidosis type I | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl-alpha-L-iduronide + H2O | - |
Homo sapiens | 4-methylumbelliferone + alpha-L-iduronic acid | - |
? | |
additional information | involved in the degradation of dermatan sulfate and heparan sulfate, deficiency in alpha-L-iduronidase causes mucopolysaccharidosis type I | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1831 | - |
NaCl | pH 2.8, 37°C, enzyme from healthy individuals | Homo sapiens |