Literature summary for 3.2.1.62 extracted from

Arribas, J.C.; Herrero, A.G.; Martin-Lomas, M.; Canada, F.J.; He, S.; Withers, S.G.
Differential mechanism-based labeling and unequivocal activity assignment of the two active sites of intestinal lactase/phlorizin hydrolase (2000), Eur. J. Biochem., 267, 6996-7005.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2',4'-dinitrophenyl-2-deoxy-2-fluoro-beta-D-galactopyranoside	inactivation of lactase hydrolase activity	Ovis aries
2',4'-dinitrophenyl-2-deoxy-2-fluoro-beta-D-glucopyranoside	inactivation of phlorizin hydrolase activity	Ovis aries
D-galactal	inactivation of lactase hydrolase activity	Ovis aries
D-glucal	inactivation of lactase hydrolase activity	Ovis aries

Organism

Organism	UniProt	Comment	Textmining
Ovis aries	-	lamb, bifunctional lactase/phlorizin hydrolase complex	-

Subunits

Subunits	Comment	Organism
More	phlorizin hydrolysis occurs at region III of enzyme, lactase hydrolysis occurs at region IV	Ovis aries

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Release 2023.1 (January 2023)