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Literature summary for 3.2.1.52 extracted from
- Separation and characterization of N-acetyl-beta-glucosaminidases A and P from maternal serum (1972), Biochim. Biophys. Acta, 271, 154-162.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetate | 80% inhibition with 66 mM | Homo sapiens |  |
| N-acetyl-D-galactosamine | 60% inhibition with 1 mM | Homo sapiens | |
| p-chloromercuribenzoate | form A: 93% inhibition with 0.1 mM, form P: 98% inhibition with 0.1 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.55 | - |
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside | form P | Homo sapiens | |
| 0.65 | - |
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside | form A | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 140000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-beta-D-hexosaminides + H2O | Homo sapiens | - |
N-acetyl-D-hexosamines | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
pregnant women | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amniotic fluid | - |
Homo sapiens | - |
| fetus | fetal membrane | Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| serum | cord serum and maternal serum | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside | - |
? | |
| N-acetyl-beta-D-hexosaminides + H2O | - |
Homo sapiens | N-acetyl-D-hexosamines | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
at pH 3.0, form P: loss of 3% of activity after 30 min, form A: loss of 22% of activity after 30 min | Homo sapiens |
| 50 | - |
at pH 5.0, form P: almost stable for 40 min, form A: loss of 70% of activity during 40 min | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
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Release 2023.1 (January 2023)
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