Literature summary for 3.2.1.52 extracted from

Pocsi, I.; Kiss, L.; Zsoldos-Madi, V.; Pinter, I.
Studies on the N-acetyl-beta-D-hexosaminidase B from germinating Lupinus luteus L. seeds: II. Mechanism and inhibition with some 2-acetamido-2-deoxyaldono(1-4)lactones (1990), Biochim. Biophys. Acta, 1039, 119-122.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-acetamido-2-deoxy-D-fucono(1-4)lactone	-	Lupinus luteus
2-acetamido-2-deoxy-D-galactono(1-4)lactone	-	Lupinus luteus
2-acetamido-2-deoxy-L-arabinono(1-4)lactone	-	Lupinus luteus
2-acetamido-6-azido-2,6-dideoxy-D-galactono(1-4)lactone	-	Lupinus luteus
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside	-	Lupinus luteus
thiophenyl-N-acetyl-beta-D-glucosaminide	-	Lupinus luteus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.58	-	p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside	-	Lupinus luteus
0.83	-	p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside	-	Lupinus luteus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-beta-D-hexosaminides + H2O	Lupinus luteus	-	N-acetyl-D-hexosamines	-	?

Organism

Organism	UniProt	Comment	Textmining
Lupinus luteus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(N-acetyl-D-glucosamine)4 + 3 H2O = 4 2-(acetylamino)-2-deoxy-beta-D-glucopyranose	same active site for N-glucosaminidase and N-galactosaminidase activities	Lupinus luteus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
seed	germinating seeds	Lupinus luteus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-beta-D-hexosaminides + H2O	-	Lupinus luteus	N-acetyl-D-hexosamines	-	?
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-galactopyranoside + H2O	-	Lupinus luteus	2-acetamido-2-deoxy-D-galactose + p-nitrophenol	-	?
p-nitrophenyl-beta-2-acetamido-2-deoxy-D-glucopyranoside + H2O	-	Lupinus luteus	2-acetamido-2-deoxy-D-glucose + p-nitrophenol	-	?

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Release 2023.1 (January 2023)