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Literature summary for 3.2.1.48 extracted from

  • Lee, S.H.; Yu, S.Y.; Nakayama, J.; Khoo, K.H.; Stone, E.L.; Fukuda, M.N.; Marth, J.D.; Fukuda, M.
    Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation (2010), J. Biol. Chem., 285, 37683-37692.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
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 Homo sapiens
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HT-29 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
sucrase isomaltase
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 Mus musculus
sucrase isomaltase
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 Homo sapiens

General Information

General Information Comment Organism
physiological function core2 1,6-N-acetylglucosaminyltransferase-2 knockdown significantly reduces cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV in Caco-2 cells. Overexpression of the core3 structure in HT-29 cells attenuates cell surface expression of both enzymes Homo sapiens
physiological function the fully glycosylated mature form of sucrase isomaltase is decreased in core2 1,6-N-acetylglucosaminyltransferase-2 knock-out mice but not in core2 N-acetylglucosaminyltransferase-3 nulls. Expression of sucrase isomaltase and dipeptidyl peptidase-IV is dramatically reduced in core2 1,6-N-acetylglucosaminyltransferase-1-3 triple knock-out mice. Goblet cells in the upper part of the crypt show impaired maturation in the core2 O-glycan-deficient mice Mus musculus