Literature summary for 3.2.1.48 extracted from

Kim, K.Y.; Nam, K.A.; Kurihara, H.; Kim, S.M.
Potent alpha-glucosidase inhibitors purified from the red alga Grateloupia elliptica (2008), Phytochemistry, 69, 2820-2825.

Search for more literature for 3.2.1.48

Application

Application	Comment	Organism
medicine	one therapeutic approach for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibition of alpha-glucosidase. Bromophenols of Grateloupia elliptica have potential as natural nutraceuticals to prevent diabetes mellitus because of their high a-glucosidase inhibitory activity	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
2,4,6-tribromophenol	purified from the red alga Grateloupia elliptica	Rattus norvegicus
2,4-Dibromophenol	purified from the red alga Grateloupia elliptica	Rattus norvegicus
acarbose	-	Rattus norvegicus
additional information	compounds with alpha-glucosidase inhibitory activity are preliminarily screened and purified from ten different seaweeds (two green, four brown, and four red). The alpha-glucosidase inhibitory activity of the MeOH H2O (4:1, v/v) extract of Polyopes lancifolia at 5 mg/ml is highest at 52.2%, followed by Grateloupia elliptica (42.0%), Sargassum thunbergii (24.3%), and Grateloupia. lanceolata (22.0%) in decreasing order	Rattus norvegicus
voglibose	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sucrose + H2O	-	Rattus norvegicus	alpha-D-glucose + D-fructose	-	?

Synonyms

Synonyms	Comment	Organism
intestinal sucrase	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00002	-	-	Rattus norvegicus	acarbose
0.00006	-	-	Rattus norvegicus	voglibose
0.0036	-	-	Rattus norvegicus	2,4-Dibromophenol
0.0042	-	-	Rattus norvegicus	2,4,6-tribromophenol

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Release 2023.1 (January 2023)