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Literature summary for 3.2.1.48 extracted from

  • Montgomery, R.K.; Sybicki, M.A.; Forcier, A.G.; Grand, R.J.
    Rat intestinal microvillus membrane sucrase-isomaltase is a single high molecular weight protein and fully active enzyme in the absence of luminal factors (1981), Biochim. Biophys. Acta, 661, 346-349.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
19.7
-
 sucrose
-
 Rattus rattus
20
-
 sucrose
-
 Rattus rattus

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
 1 * 140000 - 160000 + 1 * 140000 -160000 2 large subunits, EC 3.2.1.48 and EC 3.2.1.10, functional dimer, SDS-PAGE Rattus rattus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
maltose + H2O Rattus rattus
-
 2 glucose
-
 ?
sucrose + H2O Rattus rattus
-
 D-glucose + D-fructose
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus rattus
-
 rat, single protein with sucrase and isomaltase activity
-

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.51
-
-
 Rattus rattus
1.46
-
 adult rats Rattus rattus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
maltose + H2O
-
 Rattus rattus 2 glucose
-
 ?
sucrose + H2O
-
 Rattus rattus D-glucose + D-fructose
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 140000 - 160000 + 1 * 140000 -160000 2 large subunits, EC 3.2.1.48 and EC 3.2.1.10, functional dimer, SDS-PAGE Rattus rattus