Literature summary for 3.2.1.45 extracted from

Yang, C.; Swallows, C.L.; Zhang, C.; Lu, J.; Xiao, H.; Brady, R.O.; Zhuang, Z.
Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones (2014), Proc. Natl. Acad. Sci. USA, 111, 249-254.

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Activating Compound

Activating Compound	Comment	Organism	Structure
celastrol	significantly increases the quantity and catalytic activity of the enzyme by reducing protein degradation	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
L444P	the mutant shows strongly reduced activity	Homo sapiens
N370S	the mutant shows reduced activity	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glucocerebroside + H2O	Homo sapiens	-	ceramide + D-glucose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glucocerebroside + H2O	-	Homo sapiens	ceramide + D-glucose	-	?

Synonyms

Synonyms	Comment	Organism
Gcase	-	Homo sapiens
glucocerebrosidase	-	Homo sapiens

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Release 2023.1 (January 2023)