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Literature summary for 3.2.1.45 extracted from

  • Brumshtein, B.; Aguilar-Moncayo, M.; Benito, J.M.; Garcia Fernandez, J.M.; Silman, I.; Shaaltiel, Y.; Aviezer, D.; Sussman, J.L.; Futerman, A.H.; Ortiz Mellet, C.
    Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues (2011), Org. Biomol. Chem., 9, 4160-4167.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex beta-cyclodextrin and either 5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin or 5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin, microbatch under oil method, using 0.2 M (NH4)2SO4, 0.1 M Tris pH 6.5, and 25% (w/v) PEG3350 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin potent inhibitor Homo sapiens
5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin potent inhibitor Homo sapiens
6-amino-6-deoxy-5-N,6-N-[N'-(n-octyl)iminomethylidene]nojirimycin
-
Homo sapiens
additional information isofagomine is not specific for the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucosylceramide + H2O
-
Homo sapiens beta-D-glucose + ceramide
-
?

Synonyms

Synonyms Comment Organism
acid beta-glucosidase
-
Homo sapiens
beta-glucocerebrosidase
-
Homo sapiens
GlcCerase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction mutations in the gene encoding for acid beta-glucosidase result in Gaucher disease Homo sapiens