Literature summary for 3.2.1.45 extracted from

Goker-Alpan, O.; Wiggs, E.A.; Eblan, M.J.; Benko, W.; Ziegler, S.G.; Sidransky, E.; Schiffmann, R.
Cognitive outcome in treated patients with chronic neuronopathic Gaucher disease (2008), J. Pediatr., 153, 89-94.

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Application

Application	Comment	Organism
medicine	study on children with type 3 Gaucher disease who had received enzyme replacement therapy or a bone marrow transplant. 60% of subjects have intelectual skills below average with significant discrepancies between verbal and performance IQ. No correlation between intelligence measures and genotype or the extent of systemic involvement. The dosage, age at initiation, and the length of enzyme replacement therapy had no significant effect on IQ scores	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	children with chronic neuronopathic Gaucher disease	-

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Release 2023.1 (January 2023)