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Literature summary for 3.2.1.25 extracted from
- Evidence for two distinct forms of mammalian beta-mannosidase (1982), J. Biol. Chem., 257, 3369-3371.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SDS | - |
Capra hircus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.7 | - |
p-nitrophenyl-beta-D-mannoside | lysosomal, acidic enzyme | Capra hircus | |
| 5 | - |
p-nitrophenyl-beta-D-mannoside | nonlysosomal, neutral enzyme | Capra hircus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | goat liver contains both an acid lysosomal beta-mannosidase, deficient in beta-mannosidosis, and a neutral nonlysosomal beta-mannosidase | Capra hircus | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Capra hircus | goat liver contains both a lysosomal beta-mannosidase, acidic enzyme form, deficient in beta-mannosidosis, and a neutral nonlysosomal | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Capra hircus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | goat liver contains both a lysosomal beta-mannosidase, acidic enzyme form, deficient in beta-mannosidosis, and a neutral nonlysosomal | Capra hircus | ? | - |
? | |
| p-nitrophenyl-beta-D-mannoside + H2O | p-nitrophenyl-beta-D-mannopyranoside | Capra hircus | p-nitrophenol + alpha-D-mannose | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
2 h, more than 70% loss of activity | Capra hircus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | nonlysosomal neutral enzyme | Capra hircus |
| 5 | 5.5 | lysosomal acidic enzyme | Capra hircus |
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