Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2:3,4-di-O-isopropylidene-6-(4-phenyl-1H-1,2,3-triazole-1-yl)-alpha-D-galactopyranose | 99.4% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
1,2:5,6-di-O-isopropylidene-3-(4-phenyl-1H-1,2,3-triazole-1-yl)-alpha-D-allofuranose | 73.1% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
5-deoxy-1,2-O-isopropylidene-5-(4-hydroxymethyl-1H-1,2,3-triazole-1-yl)-alpha-D-xylofuranose | 68.8% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
5-deoxy-1,2-O-isopropylidene-5-(4-phenyl-1H-1,2,3-triazole-1-yl)-alpha-D-xylofuranose | 87.9% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
5-deoxy-1,2-O-isopropylidene-5-[4-(1-cyclohexene)-1H-1,2,3-triazole-1-yl]-alpha-D-xylofuranose | 33.3% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-(4-phenyl-1H-1,2,3-triazol-1-yl)-b-D-ribofuranoside | 94.4% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-(4-phenyl-1H-1,2,3-triazol-1-yl)-beta-D-ribofuranoside | - |
Saccharomyces cerevisiae | |
methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-(4-propyl-1H-1,2,3-triazol-1-yl)-beta-D-ribofuranoside | 44.9% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]-beta-D-ribofuranoside | 98.4% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-[4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-1H-1,2,3-triazol-1-yl]-beta-D-ribofuranoside | 79.5% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-5-[4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | 98.5% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-5-[4-(2-hydroxy-4-methylpentan-2-yl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | - |
Saccharomyces cerevisiae | |
methyl 5-deoxy-5-[4-(2-hydroxybutan-2-yl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | 41.1% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-5-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | 60.2% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-5-[4-(ethoxycarbonyl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | 98.0% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-deoxy-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | 46.5% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-[4-(3-chloropropyl)-1H-1,2,3-triazol-1-yl]-5-deoxy-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | 99.5% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-[4-(cyclohex-1-en-1-yl)-1H-1,2,3-triazol-1-yl]-5-deoxy-2,3-O-(1-methylethylidene)-b-D-ribofuranoside | 98.1% inhibition at 0.5 mM | Saccharomyces cerevisiae | |
methyl 5-[4-(cyclohex-1-en-1-yl)-1H-1,2,3-triazol-1-yl]-5-deoxy-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | - |
Saccharomyces cerevisiae | |
methyl 5-[4-[(acetyloxy)methyl]-1H-1,2,3-triazol-1-yl]-5-deoxy-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | - |
Saccharomyces cerevisiae | |
additional information | synthesis, biological activity, and molecular modeling studies of 1H-1,2,3-triazole derivatives of carbohydrates as alpha-glucosidases inhibitors. Methyl-2,3-O-isopropylidene-beta-D-ribofuranosides, such as the 4-(1-cyclohexenyl)-1,2,3-triazole derivative, are among the most active compounds, showing up to 25fold higher inhibitory potency than the complex oligosaccharide acarbose. Docking study and homology modeling, transition-state-mimicking mechanism, overview | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
MAL12 | - |
Saccharomyces cerevisiae |
maltase | - |
Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0038 | - |
pH and temperature not specified in the publication | Saccharomyces cerevisiae | methyl 5-[4-(cyclohex-1-en-1-yl)-1H-1,2,3-triazol-1-yl]-5-deoxy-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | |
0.0052 | - |
pH and temperature not specified in the publication | Saccharomyces cerevisiae | methyl 5-deoxy-5-[4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | |
0.0057 | - |
pH and temperature not specified in the publication | Saccharomyces cerevisiae | methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]-beta-D-ribofuranoside | |
0.0149 | - |
pH and temperature not specified in the publication | Saccharomyces cerevisiae | methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-(4-phenyl-1H-1,2,3-triazol-1-yl)-beta-D-ribofuranoside | |
0.0151 | - |
pH and temperature not specified in the publication | Saccharomyces cerevisiae | methyl 5-deoxy-5-[4-(ethoxycarbonyl)-1H-1,2,3-triazol-1-yl]-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside | |
0.0247 | - |
pH and temperature not specified in the publication | Saccharomyces cerevisiae | methyl 5-deoxy-2,3-O-(1-methylethylidene)-5-[4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-1H-1,2,3-triazol-1-yl]-beta-D-ribofuranoside |