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Literature summary for 3.2.1.20 extracted from

  • Prabhakar Reddy, P.; Tiwari, A.K.; Ranga Rao, R.; Madhusudhana, K.; Rama Subba Rao, V.; Ali, A.Z.; Suresh Babu, K.; Madhusudana Rao, J.
    New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes (2009), Bioorg. Med. Chem. Lett., 19, 2562-2565.
    View publication on PubMed
Search for more literature for 3.2.1.20

Application

Application Comment Organism
medicine enzyme inhibition as therapeutic target for diabetes, in cancer, viral infections and in lysosomal storage diseases Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-2-hydroxy-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
-
 Rattus norvegicus
(4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-1-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-2-yl acetate
-
 Rattus norvegicus
(4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3-(hydroxymethyl)-4a,8,8-trimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
-
 Rattus norvegicus
(4S,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
-
 Rattus norvegicus
4-[(E)-2-[(1S,4aS,8aR)-2,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]ethenyl]furan-2(5H)-one
-
 Rattus norvegicus
Hedychia lactone B
-
 Rattus norvegicus
Spicatanol
-
 Rattus norvegicus
Spicatanol methyl ether
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Rattus norvegicus 4-nitrophenol + alpha-D-glucose
-
 ?

Synonyms

Synonyms Comment Organism
alpha-glucosidase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 0.1 mg/ml, 11.3% enzyme inhibition Rattus norvegicus Hedychia lactone B
additional information
-
 0.1 mg/ml, 13.5% enzyme inhibition Rattus norvegicus (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-2-hydroxy-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
additional information
-
 0.1 mg/ml, 15.1% enzyme inhibition Rattus norvegicus (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3-(hydroxymethyl)-4a,8,8-trimethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
additional information
-
 0.1 mg/ml, 25.7% enzyme inhibition Rattus norvegicus (4R,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-1-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-2-yl acetate
additional information
-
 0.1 mg/ml, 35.1% enzyme inhibition Rattus norvegicus 4-[(E)-2-[(1S,4aS,8aR)-2,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]ethenyl]furan-2(5H)-one
additional information
-
 0.1 mg/ml, 54.1% enzyme inhibition Rattus norvegicus Spicatanol methyl ether
additional information
-
 0.1 mg/ml, 55.6% enzyme inhibition Rattus norvegicus (4S,4aR,8aS)-4-[(E)-2-(furan-3-yl)ethenyl]-3,4a,8,8-tetramethyl-4a,5,6,7,8,8a-hexahydronaphthalen-1(4H)-one
0.0341
-
 0.1 mg/ml, 89.5% enzyme inhibition Rattus norvegicus Spicatanol