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Literature summary for 3.2.1.20 extracted from

  • Hakamata, W.; Muroi, M.; Kadokura, K.; Nishio, T.; Oku, T.; Kimura, A.; Chiba, S.; Takatsuki, A.
    Aglycon specificity profiling of alpha-glucosidases using synthetic probes (2005), Bioorg. Med. Chem. Lett., 15, 1489-1492.
    View publication on PubMed
Search for more literature for 3.2.1.20

Inhibitors

Inhibitors Comment Organism Structure
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol inhibition of isozymes HBGase I and HBGase II Apis mellifera
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Aspergillus niger
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Beta vulgaris
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol mixed inhibition type Geobacillus stearothermophilus
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Oryza sativa
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol competitive Saccharomyces cerevisiae
2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol inhibition of isozymes HBGase I and HBGase II Apis mellifera
2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozyme HBGase I Apis mellifera
2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozymes HBGase I and HBGase II Apis mellifera
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Rattus norvegicus
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol competitive Saccharomyces cerevisiae
2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Saccharomyces cerevisiae
2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozymes HBGase II and HBGase III Apis mellifera
2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Saccharomyces cerevisiae
2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozyme HBGase II Apis mellifera
2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Aspergillus niger
2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol inhibition of isozyme HBGase II Apis mellifera
2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol
-
 Beta vulgaris
2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol
-
 Oryza sativa
2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol
-
 Zea mays subsp. mays
castanospermine
-
 Apis mellifera
castanospermine
-
 Aspergillus niger
castanospermine
-
 Beta vulgaris
castanospermine
-
 Geobacillus stearothermophilus
castanospermine
-
 Oryza sativa
castanospermine
-
 Rattus norvegicus
castanospermine
-
 Saccharomyces cerevisiae
castanospermine
-
 Zea mays subsp. mays
conduritol B epoxide
-
 Apis mellifera
conduritol B epoxide
-
 Aspergillus niger
conduritol B epoxide
-
 Beta vulgaris
conduritol B epoxide
-
 Geobacillus stearothermophilus
conduritol B epoxide
-
 Oryza sativa
conduritol B epoxide
-
 Rattus norvegicus
conduritol B epoxide
-
 Saccharomyces cerevisiae
conduritol B epoxide
-
 Zea mays subsp. mays
D-gluconolactone
-
 Apis mellifera
D-gluconolactone
-
 Aspergillus niger
D-gluconolactone
-
 Beta vulgaris
D-gluconolactone
-
 Geobacillus stearothermophilus
D-gluconolactone
-
 Oryza sativa
D-gluconolactone
-
 Rattus norvegicus
D-gluconolactone
-
 Saccharomyces cerevisiae
D-gluconolactone
-
 Zea mays subsp. mays
deoxynojirimycin
-
 Apis mellifera
deoxynojirimycin
-
 Aspergillus niger
deoxynojirimycin
-
 Beta vulgaris
deoxynojirimycin
-
 Geobacillus stearothermophilus
deoxynojirimycin
-
 Oryza sativa
deoxynojirimycin
-
 Rattus norvegicus
deoxynojirimycin
-
 Saccharomyces cerevisiae
deoxynojirimycin
-
 Zea mays subsp. mays
additional information inhibition of isozymes, IC50 values, overview, no inhibition of all isozymes by 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol Apis mellifera
additional information no inhibition by 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, IC50 values, overview Aspergillus niger
additional information IC50 values, overview Beta vulgaris
additional information no inhibition by 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, IC50 values, overview Geobacillus stearothermophilus
additional information IC50 values, overview Oryza sativa
additional information no inhibition by 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol, 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(3-hydroxy-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(2,2-dimethyl-1-methylidenepropyl)amino]-D-glycero-L-gulo-heptitol, IC50 values of alpha-glucosidase I and alpha-glucosidase II, overview Rattus norvegicus
additional information no inhibition by 2,6-anhydro-7-deoxy-7-([1-(hydroxymethyl)ethenyl]amino)-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(4-hydroxy-1-methylidenebutyl)amino]-D-glycero-L-gulo-heptitol, 2,6-anhydro-7-deoxy-7-[(6-hydroxy-1-methylidenehexyl)amino]-D-glycero-L-gulo-heptitol, and 2,6-anhydro-7-deoxy-7-[(1-methylethenyl)amino]-D-glycero-L-gulo-heptitol, IC50 values, overview Saccharomyces cerevisiae
additional information IC50 values, overview Zea mays subsp. mays

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the isozymes are endoplasmic reticulum processing alpha-glucosidases Rattus norvegicus 5783
-
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Apis mellifera
-
 isozymes HBGase I-III
-
Aspergillus niger
-
-
-
Beta vulgaris
-
 sugar beet
-
Geobacillus stearothermophilus
-
-
-
Oryza sativa
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Zea mays subsp. mays
-
 flint corn
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate aglycon specificity profiling, overview Beta vulgaris ?
-
 ?
additional information substrate aglycon specificity profiling, overview Rattus norvegicus ?
-
 ?
additional information substrate aglycon specificity profiling, overview Saccharomyces cerevisiae ?
-
 ?
additional information substrate aglycon specificity profiling, overview Geobacillus stearothermophilus ?
-
 ?
additional information substrate aglycon specificity profiling, overview Aspergillus niger ?
-
 ?
additional information substrate aglycon specificity profiling, overview Apis mellifera ?
-
 ?
additional information substrate aglycon specificity profiling, overview Oryza sativa ?
-
 ?
additional information substrate aglycon specificity profiling, overview Zea mays subsp. mays ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha-glucosidase I
-
 Rattus norvegicus
alpha-glucosidase II
-
 Rattus norvegicus
HBGase I
-
 Apis mellifera
HBGase II
-
 Apis mellifera
HBGase III
-
 Apis mellifera
More the enzyme belongs to the alpha-glucosidase family 13 Saccharomyces cerevisiae
More the enzyme belongs to the alpha-glucosidase family 13 Geobacillus stearothermophilus
More the enzyme belongs to the alpha-glucosidase family 31 Beta vulgaris
More the enzyme belongs to the alpha-glucosidase family 31 Aspergillus niger
More the enzyme belongs to the alpha-glucosidase family 31 Oryza sativa
More the enzyme belongs to the alpha-glucosidase family 31 Zea mays subsp. mays

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.13
-
 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Saccharomyces cerevisiae
0.5
-
 2,6-anhydro-7-deoxy-7-[(1-phenylethenyl)amino]-D-glycero-L-gulo-heptitol
-
 Saccharomyces cerevisiae
0.58
-
 2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-D-glycero-D-ido-heptitol
-
 Geobacillus stearothermophilus