Cloned (Comment) | Organism |
---|---|
recombinant expression of the mature peptide-coding region in Pichia pastoris strain GS115 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Na+ | activates, best at 75 mM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21508 | - |
x * 21508, sequence calculation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86SG7 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from Pichia pastoris strain GS115 by chitin affinity chromatography and gel filtration to homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | weak enzyme expression in the conjuctival sample, strong expression in the lacrimal gland sample | Homo sapiens | - |
tear | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a suspension of Micrococcus lysodeikticus is used as a substrate for HLysG2 | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 21508, sequence calculation | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
g-type lysozyme | - |
Homo sapiens |
Goose-type lysozyme | - |
Homo sapiens |
HLysG2 | - |
Homo sapiens |
lysozyme g-like 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
recombinant enzyme | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
recombinant enzyme | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | lysozyme plays an important role in human innate immunity by causing bacterial cell lysis. Recombinant HlysG2 inhibits Gram-positive bacterial growth, but does not inhibit Gram-negative bacterial and Candida albicans growth. HLysG2 is a potent antibacterial protein that may play a role in the innate immunity of the human eye | Homo sapiens |