Literature summary for 3.2.1.166 extracted from

Gong, F.; Jemth, P.; Escobar Galvis, M.L.; Vlodavsky, I.; Horner, A.; Lindahl, U.; Li, J.P.
Processing of macromolecular heparin by heparanase (2003), J. Biol. Chem., 278, 35152-35158.

Search for more literature for 3.2.1.166

Inhibitors

Inhibitors	Comment	Organism	Structure
heparin	commercial heparin is a powerful inhibitor of heparanase action toward antithrombin-binding oligosaccharides	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y251	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heparin + H2O	heparanase cleaves macromolecular heparin at multiple sites. Heparanase primarily cleaves target structures distinct from the antithrombin-binding sequence	Homo sapiens	?	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00002	-	heparanase action toward antithrombin-binding oligosaccharides	Homo sapiens	heparin

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)