Literature summary for 3.2.1.143 extracted from

Meyer-Ficca, M.L.; Meyer, R.G.; Coyle, D.L.; Jacobson, E.L.; Jacobson, M.K.
Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments (2004), Exp. Cell Res., 297, 521-532.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	isoforms hPARG102, hPARG99, which account for most of enzyme activity in the absence and presence of genotoxic stress	Homo sapiens	5737	-
nucleus	isoform hPARG111, due to nuclear targeting signal in exon 1	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86W56	two splice variants of enzyme mRNA leading to isoforms of 102 kDa, hPARG102, and of 99 kDA, hPARG99, in addition to full-length protein hPARG111	-

Subunits

Subunits	Comment	Organism
More	two splice variants of enzyme mRNA leading to isoforms of 102 kDa, hPARG102, and of 99 kDA, hPARG99, in addition to full-length protein hPARG111	Homo sapiens

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Release 2023.1 (January 2023)