Inhibitors | Comment | Organism | Structure |
---|---|---|---|
12-O-tetradecanoyl-phorbol-13-acetate | reduction of nuclear enzyme activity to 30-40% of control, cytosolic activity remains unchanged. Reduction is suppressed by protein kinase C inhibitor H7. Enzyme expression is reduced in presence of 12-O-tetradecanoyl-phorbol-13-acetate | Homo sapiens | |
Tannic acid | continous decrease in activity of nuclear enzyme activity, reduction in enzyme expression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
nucleus | reduction of nuclear enzyme activity to 30-40% of control by treatment with 12-O-tetradecanoyl-phorbol-13-acetate, cytosolic activity remains unchanged. Reduction is suppressed by protein kinase C inhibitor H7 | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | transient decrease in nuclear enzyme activity is important for the onset of differentiation of HL-60 cells to macrophage-like cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86W56 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | promyelocytic leukemia cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | transient decrease in nuclear enzyme activity is important for the onset of differentiation of HL-60 cells to macrophage-like cells | Homo sapiens | ? | - |
? |