Literature summary for 3.2.1.143 extracted from

Ohashi, S.; Kanai, M.; Hanai, S.; Uchiumi, F.; Maruta, H.; Tanuma, S.; Miwa, M.
Subcellular localization of poly(ADP-ribose) glycohydrolase in mammalian cells (2003), Biochem. Biophys. Res. Commun., 307, 915-921.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
centrosome	during mitosis	Homo sapiens	5813	-
cytoplasm	during mitosis	Homo sapiens	5737	-
nucleus	during interphase, exclusively	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	shuttling of enzyme between nucleus and cytoplasm and proper control of poly(ADP-ribose) metabolism throughout cell cycle may be an important role in regulating cell cycle progression and centrosome duplication	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant protein with GFP- or Myc-tag, subcellular distribution of enzmye changes dramatically during cell cycle	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	shuttling of enzyme between nucleus and cytoplasm and proper control of poly(ADP-ribose) metabolism throughout cell cycle may be an important role in regulating cell cycle progression and centrosome duplication	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)