Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.130 extracted from

  • Stehli, J.; Torossi, T.; Ziak, M.
    Triple arginines in the cytoplasmic tail of endomannosidase are not essential for type II membrane topology and Golgi localization (2008), Cell. Mol. Life Sci., 65, 1609-1619.
    View publication on PubMed
Search for more literature for 3.2.1.130

Cloned(Commentary)

Cloned (Comment) Organism
endomannosidase subcloned into the HindIII/XhoI site of the pcDNA6 vector in frame with the myc-tag or into the Hind III/Bam HI site of the pEGFP vector for endomannosidase, expressed in CHO-K1 cells. CHO-K1 cells expressing DELTAsig-rEndo or DELTATMD-rEndo Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information in CHO-K1 cells expressing DELTAsig-rEndo, lacking the whole signal sequence, or DELTATMD-rEndo, lacking the transmembrane domain, endomannosidase is undetectable. DELTACT-rEndo, lacking the cytoplasmic tail, exhibits an ER localization and fails to maintain a type II membrane topology Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm its cytoplasmic domain is required for its efficient Golgi localization. Proper topology rather than the presence of positively charged amino acids in the cytoplasmic tail is critical for Golgi localization of rat endomannosidase Rattus norvegicus 5737
-
membrane rat endomannosidase is a type II membrane protein, its transmembrane domain is required for its efficient Golgi localization, i.e. is necessary for the Golgi retention Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
endomannosidase
-
 Rattus norvegicus