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Literature summary for 3.2.1.128 extracted from
- Biocatalytic properties of a novel crude glycyrrhizin hydrolase from the liver of the domestic duck (2006), J. Mol. Catal. B, 43, 148-152.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | slight stimulatory effect | Anas platyrhynchos |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | slight inhibitory effect | Anas platyrhynchos | |
| Cu2+ | strong inhibitory effect | Anas platyrhynchos | |
| Fe2+ | slight inhibitory effect | Anas platyrhynchos | |
| glycyrrhizinic acid | inhibits the crude enzyme activity when concentration is up to 60 mM | Anas platyrhynchos | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10.98 | - |
glycyrrhizinic acid | - |
Anas platyrhynchos | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | slight stimulatory effect | Anas platyrhynchos | |
| Mn2+ | slight stimulatory effect | Anas platyrhynchos | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anas platyrhynchos | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Anas platyrhynchos | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycyrrhizinic acid + H2O | - |
Anas platyrhynchos | glycyrrhetic acid monoglucuronide + beta-D-glucose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GL hydrolase | - |
Anas platyrhynchos |
| glycyrrhizin hydrolase | - |
Anas platyrhynchos |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
enzyme activity gradually declines at temperatures beyond 55°C | Anas platyrhynchos |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 55 | - |
stable at temperatures below 55°C. When exposed to 70°C, it loses 90% of its activity | Anas platyrhynchos |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Anas platyrhynchos |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.8 | 6.2 | - |
Anas platyrhynchos |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
stable only at pH 6. The enzyme loses its activity entirely when pH is beyond 8.0. It is more prone to inactivity at high pH conditions than at low pH conditions | Anas platyrhynchos |
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