Application | Comment | Organism |
---|---|---|
medicine | progression-free survival significantly longer in high FUCA activity group than in low FUCA activity group, not correlated to clinical response to trastuzumab but maybe useful as biomarker for predicting progression-free survival for trastuzumab treatment | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl-alpha-L-fucopyranoside + H2O | Homo sapiens | - |
4-nitrophenol + L-fucose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
5.5 micromol/min/l, progressive disease group | Homo sapiens |
additional information | - |
5.9 micromol/min/l, nonresponders to trastuzumab | Homo sapiens |
additional information | - |
6.1 micromol/min/l, spectrophotometer citrate buffer pH 4.5, 3 h incubation at 37 degree Celsius, optical density at 405 nm, average over all patient | Homo sapiens |
additional information | - |
6.3 micromol/min/l, non-progressive disease group | Homo sapiens |
additional information | - |
7.2 micromol/min/l, responders to trastuzumab | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl-alpha-L-fucopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + L-fucose | - |
? | |
4-nitrophenyl-alpha-L-fucopyranoside + H2O | substrate incubated with plasma sample of breast cancer patients treated with anti-cancer monoclonal antibody trastuzumbal | Homo sapiens | 4-nitrophenol + L-fucose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-L fucosidase | - |
Homo sapiens |
FucA | - |
Homo sapiens |