Application | Comment | Organism |
---|---|---|
medicine | less oxidised dextrans conjugating proportionally less 5-aminosalicylic acid successfully hydrolysed by dextranase, suggest their potential applications for the treatment of Crohns disease in the distal ileum and proximal colon | Penicillium sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium sp. | - |
- |
- |
Penicillium sp. D5884 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dextran + H2O | extent of hydrolysis of 5-aminosalicylic acid-dextran conjugates (secondary amines) by dextranase is in part controlled by the degree of oxidation and by the amount of conjugated 5-aminosalicylic acid. Less oxidised dextrans (12%) conjugating proportionally less 5-aminosalicylic acid are successfully hydrolysed by dextranase | Penicillium sp. | ? | - |
? | |
dextran + H2O | extent of hydrolysis of 5-aminosalicylic acid-dextran conjugates (secondary amines) by dextranase is in part controlled by the degree of oxidation and by the amount of conjugated 5-aminosalicylic acid. Less oxidised dextrans (12%) conjugating proportionally less 5-aminosalicylic acid are successfully hydrolysed by dextranase | Penicillium sp. D5884 | ? | - |
? | |
additional information | dextrans with a maximum degree of oxidation (93%) giving maximum conjugation of 5-aminosalicylic acid are resistant to dextranase hydrolysis | Penicillium sp. | ? | - |
? | |
additional information | dextrans with a maximum degree of oxidation (93%) giving maximum conjugation of 5-aminosalicylic acid are resistant to dextranase hydrolysis | Penicillium sp. D5884 | ? | - |
? |