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Literature summary for 3.2.1.106 extracted from
- Importance of glycosidases in mammalian glycoprotein biosynthesis (1999), Biochim. Biophys. Acta, 1473, 96-107.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents | Mammalia |
| pharmacology | glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-deoxynojirimycin | - |
Homo sapiens |  |
| 1-deoxynojirimycin | - |
Mammalia | |
| castanospermine | - |
Mammalia | |
| additional information | - |
Homo sapiens | |
| additional information | no inhibition by bromoconduritol | Mammalia |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | endoplasmic reticulum-resident glycoprotein | Mammalia | 5783 | - |
| endoplasmic reticulum | endoplasmic reticulum-resident glycoprotein | Homo sapiens | 5783 | - |
| membrane | membrane-bound | Mammalia | 16020 | - |
| membrane | membrane-bound | Homo sapiens | 16020 | - |
| membrane | type-II transmembrane protein | Mammalia | 16020 | - |
| membrane | type-II transmembrane protein | Homo sapiens | 16020 | - |
| additional information | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | - |
Homo sapiens | |
| additional information | no requirement for divalent cations | Mammalia |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 92000 | - |
calculated from nucleotide sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glc3Man9GlcNAc2 + H2O | Mammalia | hydrolyses specifically terminal alpha1,2-linked glucose residue | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Homo sapiens | hydrolyses specifically terminal alpha1,2-linked glucose residue | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Mammalia | specific involvement in the N-linked oligosaccharide-processing pathway | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Homo sapiens | specific involvement in the N-linked oligosaccharide-processing pathway | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Mammalia | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Homo sapiens | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Mammalia | involved in processing of asparagine-linked oligosaccharides | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | Homo sapiens | involved in processing of asparagine-linked oligosaccharides | ? | - |
? | |
| additional information | Mammalia | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | ? | - |
? | |
| additional information | Homo sapiens | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | ? | - |
? | |
| additional information | Mammalia | involved in processing of asparagine-linked oligosaccharides | ? | - |
? | |
| additional information | Homo sapiens | involved in processing of asparagine-linked oligosaccharides | ? | - |
? | |
| additional information | Mammalia | processing alpha-glucosidases in the endoplasmic reticulum act in concert with two lectin chaperones, membrane-bound calnexin and its soluble homolog calreticulin, and with the enzyme UDP-glucose:glycoprotein glucosyltransferase to facilitate glycoprotein folding | ? | - |
? | |
| additional information | Homo sapiens | processing alpha-glucosidases in the endoplasmic reticulum act in concert with two lectin chaperones, membrane-bound calnexin and its soluble homolog calreticulin, and with the enzyme UDP-glucose:glycoprotein glucosyltransferase to facilitate glycoprotein folding | ? | - |
? | |
| additional information | Mammalia | role in the folding of newly formed glycoprotein and in endoplasmic reticulum quality control | ? | - |
? | |
| additional information | Homo sapiens | role in the folding of newly formed glycoprotein and in endoplasmic reticulum quality control | ? | - |
? | |
| additional information | Mammalia | essential for maturation of glycoproteins containing N-glycans in mammalian cells, alpha-glucosidase I has been conserved through eukaryotic evolution from yeast to mammals | ? | - |
? | |
| additional information | Mammalia | involved in the formation of high mannose and complex glycoproteins | ? | - |
? | |
| additional information | Homo sapiens | involved in the formation of high mannose and complex glycoproteins | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mammalia | - |
generally present in mammalian tissues | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glc3Man9GlcNAc2 + H2O | hydrolyses specifically terminal alpha1,2-linked glucose residue | Mammalia | D-glucose + Glc2Man9GlcNAc2 | - |
? | |
| Glc3Man9GlcNAc2 + H2O | hydrolyses specifically terminal alpha1,2-linked glucose residue | Homo sapiens | D-glucose + Glc2Man9GlcNAc2 | - |
? | |
| Glc3Man9GlcNAc2 + H2O | hydrolyses specifically terminal alpha1,2-linked glucose residue | Mammalia | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | hydrolyses specifically terminal alpha1,2-linked glucose residue | Homo sapiens | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | specific involvement in the N-linked oligosaccharide-processing pathway | Mammalia | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | specific involvement in the N-linked oligosaccharide-processing pathway | Homo sapiens | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | Mammalia | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | Homo sapiens | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | involved in processing of asparagine-linked oligosaccharides | Mammalia | ? | - |
? | |
| Glc3Man9GlcNAc2 + H2O | involved in processing of asparagine-linked oligosaccharides | Homo sapiens | ? | - |
? | |
| additional information | also acts, more slowly, on the corresponding glycolipids and glycopeptides | Mammalia | ? | - |
? | |
| additional information | also acts, more slowly, on the corresponding glycolipids and glycopeptides | Homo sapiens | ? | - |
? | |
| additional information | aryl-alpha-D-glucosides: not a substrate | Mammalia | ? | - |
? | |
| additional information | aryl-alpha-D-glucosides: not a substrate | Homo sapiens | ? | - |
? | |
| additional information | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | Mammalia | ? | - |
? | |
| additional information | involved in first step of processing of oligosaccharides after transfer from dolichyl diphosphate to proteins | Homo sapiens | ? | - |
? | |
| additional information | involved in processing of asparagine-linked oligosaccharides | Mammalia | ? | - |
? | |
| additional information | involved in processing of asparagine-linked oligosaccharides | Homo sapiens | ? | - |
? | |
| additional information | processing alpha-glucosidases in the endoplasmic reticulum act in concert with two lectin chaperones, membrane-bound calnexin and its soluble homolog calreticulin, and with the enzyme UDP-glucose:glycoprotein glucosyltransferase to facilitate glycoprotein folding | Mammalia | ? | - |
? | |
| additional information | processing alpha-glucosidases in the endoplasmic reticulum act in concert with two lectin chaperones, membrane-bound calnexin and its soluble homolog calreticulin, and with the enzyme UDP-glucose:glycoprotein glucosyltransferase to facilitate glycoprotein folding | Homo sapiens | ? | - |
? | |
| additional information | role in the folding of newly formed glycoprotein and in endoplasmic reticulum quality control | Mammalia | ? | - |
? | |
| additional information | role in the folding of newly formed glycoprotein and in endoplasmic reticulum quality control | Homo sapiens | ? | - |
? | |
| additional information | essential for maturation of glycoproteins containing N-glycans in mammalian cells, alpha-glucosidase I has been conserved through eukaryotic evolution from yeast to mammals | Mammalia | ? | - |
? | |
| additional information | involved in the formation of high mannose and complex glycoproteins | Mammalia | ? | - |
? | |
| additional information | involved in the formation of high mannose and complex glycoproteins | Homo sapiens | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
near neutral pH optimum | Mammalia |
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