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Literature summary for 3.2.1.10 extracted from

  • Natori, Y.; Sakuma, T.; Yoshimura, Y.; Kinami, K.; Hirokami, Y.; Sato, K.; Adachi, I.; Kato, A.; Takahata, H.
    Synthesis and biological evaluation of alpha-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of alpha-glucosidase inhibitors (2014), Bioorg. Med. Chem. Lett., 24, 3298-3301.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2S,3S,4S,5S)-2-(hydroxymethyl)-5-[3-(4-methylphenyl)propyl]pyrrolidine-3,4-diol
-
 Rattus norvegicus
(2S,3S,4S,5S)-2-(hydroxymethyl)-5-[4-(4-methoxyphenyl)butyl]pyrrolidine-3,4-diol
-
 Rattus norvegicus
(2S,3S,4S,5S)-2-[4-(3,5-difluorophenyl)butyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol good inhibition activities against intestinal isomaltase and sucrase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
isomaltase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00022
-
 pH 6.8, 37°C Rattus norvegicus (2S,3S,4S,5S)-2-[4-(3,5-difluorophenyl)butyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol
0.00063
-
 pH 6.8, 37°C Rattus norvegicus (2S,3S,4S,5S)-2-(hydroxymethyl)-5-[3-(4-methylphenyl)propyl]pyrrolidine-3,4-diol
0.0018
-
 pH 6.8, 37°C Rattus norvegicus (2S,3S,4S,5S)-2-(hydroxymethyl)-5-[4-(4-methoxyphenyl)butyl]pyrrolidine-3,4-diol