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Literature summary for 3.2.1.10 extracted from
- HNF-1alpha participates in glucose regulation of sucrase-isomaltase gene expression in epithelial intestinal cells (2007), Biochem. Biophys. Res. Commun., 353, 617-622.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | gene expression and enzyme activity are changed by nutritional conditions | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in type 2 diabetic patients enhanced SI enzyme activity may cause hyperglycemia, and aggravates diabetic conditions, the results of the study could be important for development of inhibitors | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-glucose | sucrase-isomaltase gene expression is negatively regulated by glucose | Homo sapiens |  |
| hepatocyte nuclear factor-1alpha | gene expression of HNF-1alpha exhibits a positive correlation with that of sucrase-isomaltase regulated by glucose | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Caco-2 cell | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| intestine | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| oligo-1,6-glucosidase | - |
Homo sapiens |
| sucrase-isomaltase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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