Crystallization (Comment) | Organism |
---|---|
X-ray diffraction structure determination and analysis at 1.35 A resolution, cocrystal structures with phosphonoacetate substrate, acetate, phosphonoformate inhibitor, and a covalently bound transition state mimic | Sinorhizobium meliloti |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Phosphonoformate | - |
Sinorhizobium meliloti |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Phosphonoacetate + H2O | Sinorhizobium meliloti | - |
acetate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sinorhizobium meliloti | Q92UV8 | gene phnA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Phosphonoacetate + H2O | - |
Sinorhizobium meliloti | acetate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PhnA | - |
Sinorhizobium meliloti |
General Information | Comment | Organism |
---|---|---|
metabolism | 2-aminoethylphosphonate is catabolized to phosphonoacetate, which is converted to acetate and inorganic phosphate by phosphonoacetate hydrolase, PhnA | Sinorhizobium meliloti |
additional information | C-P bond hydrolysis by phosphonoacetate hydrolase, structure and mechanism, overview. Structure analysis of bound substrate, product, inhibitor, and a covalently bound transition state mimic provide insight into active site features that may facilitate cleavage of the C-P bond | Sinorhizobium meliloti |