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Literature summary for 3.11.1.1 extracted from

  • Lee, S.L.; Hepburn, T.W.; Swartz, W.H.; Ammon, H.L.; Mariano, P.S.; Dunaway-Mariano, D.
    Stereochemical probe for the mechanism of P-C bond cleavage catalyzed by the Bacillus cereus phosphonoacetaldehyde hydrolase (1992), J. Am. Chem. Soc., 114, 7346-7354.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphonoacetylaldehyde + H2O Bacillus cereus
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acetaldehyde + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
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Reaction

Reaction Comment Organism Reaction ID
phosphonoacetaldehyde + H2O = acetaldehyde + phosphate double displacement mechanism proceeding via protonated Schiff base and phosphoenzyme intermediates. The mechanism involves P-C bond cleavage in a protonated Schiff base intermediate by in-line displacement by an enzyme nucleophile. Subsequent hydrolysis of the resultant acetaldehyde enamine and phosphoenzyme groups then yield acetaldehyde and phosphate Bacillus cereus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphonoacetylaldehyde + H2O
-
Bacillus cereus acetaldehyde + phosphate
-
?