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Literature summary for 3.1.99.B1 extracted from

  • Jagannathan, I.; Pepenella, S.; Hayes, J.J.
    Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation (2011), J. Biol. Chem., 286, 17521-17529.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens substrate recognition and binding, orientation of the flaps into nucleosomes is important for the cleavage, patterns, detailed overview. However, flaps within nucleosomes containing the high-affinity 601 DNA sequence are completely resistant to FEN1 cleavage regardless of orientation. Flaps within such high-affinity nucleosome binding sequences will require ATP-dependent remodeling activity for completion of base excision repair ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate recognition and binding, orientation of the flaps into nucleosomes is important for the cleavage, patterns, detailed overview. However, flaps within nucleosomes containing the high-affinity 601 DNA sequence are completely resistant to FEN1 cleavage regardless of orientation. Flaps within such high-affinity nucleosome binding sequences will require ATP-dependent remodeling activity for completion of base excision repair Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
FEN1 endonuclease
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Homo sapiens