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Literature summary for 3.1.8.2 extracted from

  • Landis, W.G.; Anderson, R.S.; Chester, N.A.; Durst, H.D.; Haley, M.V.; Johnson, D.W.; Tauber, R.M.
    The organophosphate acid anhydrases of the protozoan, Tetrahymena thermophila, and the clam, Rangia cuneata (1989), ASTM Spec. Tech. Publ., 1027, 74-81.
No PubMed abstract available
Search for more literature for 3.1.8.2

Inhibitors

Inhibitors Comment Organism Structure
Mipafox
-
 Tetrahymena thermophila

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ only Mazur-type enzyme Sus scrofa
Mn2+ only Mazur-type enzyme Tetrahymena thermophila
Mn2+ only Mazur-type enzyme Rangia cuneata

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000 30000 three enzyme types of different MW: 20000-30000, 45000-50000 and 70000-100000 Rangia cuneata
45000 50000 three enzyme types of different MW: 20000-30000, 45000-50000 and 70000-100000 Rangia cuneata
70000 100000 three enzyme types of different MW: 20000-30000, 45000-50000 and 70000-100000 Rangia cuneata

Organism

Organism UniProt Comment Textmining
Rangia cuneata
-
 clam
-
Sus scrofa
-
-
-
Tetrahymena thermophila
-
 ciliate
-

Purification (Commentary)

Purification (Comment) Organism
partial Tetrahymena thermophila
partial, 3 enzymes of different MW Rangia cuneata

Reaction

Reaction Comment Organism Reaction ID
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride squide-type enzyme: diisopropyl fluorophosphate hydrolysed more rapidly than soman, Mazur-type enzyme: soman hydrolysed more rapidly than diisopropyl fluorophosphate Sus scrofa
a
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride squide-type enzyme: diisopropyl fluorophosphate hydrolysed more rapidly than soman, Mazur-type enzyme: soman hydrolysed more rapidly than diisopropyl fluorophosphate Tetrahymena thermophila
a
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride squide-type enzyme: diisopropyl fluorophosphate hydrolysed more rapidly than soman, Mazur-type enzyme: soman hydrolysed more rapidly than diisopropyl fluorophosphate Rangia cuneata
a

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-ethyl(phenyl)phosphinate + H2O i.e. NPEPP Sus scrofa ?
-
 ?
4-nitrophenyl-ethyl(phenyl)phosphinate + H2O i.e. NPEPP Tetrahymena thermophila ?
-
 ?
4-nitrophenyl-ethyl(phenyl)phosphinate + H2O Rangia cuneata (Mazur-type enzyme): better substrate than diisopropyl fluorophosphate Rangia cuneata ?
-
 ?
diisopropyl fluorophosphate + H2O i.e. DFP Sus scrofa diisopropyl phosphate + fluoride
-
 ?
diisopropyl fluorophosphate + H2O i.e. DFP Tetrahymena thermophila diisopropyl phosphate + fluoride
-
 ?
diisopropyl fluorophosphate + H2O i.e. DFP Rangia cuneata diisopropyl phosphate + fluoride
-
 ?
additional information Tetrahymena thermophila has 5 enzyme forms, some share characteristics of both the squid and the Mazur-type DFPase Tetrahymena thermophila ?
-
 ?
sarin + H2O
-
 Sus scrofa ?
-
 ?
sarin + H2O Mazur-type enzyme Tetrahymena thermophila ?
-
 ?