Literature summary for 3.1.8.1 extracted from

Chambers, J.E.; Chambers, H.W.; Meek, E.C.; Funck, K.E.; Bhavaraju, M.H.; Gwaltney, S.R.; Pringle, R.B.
Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates (2015), Toxicol. Sci., 143, 46-53.

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Application

Application	Comment	Organism
degradation	a series of substituted phenoxyalkyl pyridinium oximes enhance the degradation of surrogates of sarin (i.e. nitrophenyl isopropyl methylphosphonate, NIMP) and VX (i.e. nitrophenyl ethyl methylphosphonate, NEMP). Neither NIMP nor NEMP is hydrolyzed effectively by paraoxonase PON1 if one of these oximes is absent. In the presence of eight novel oximes, PON1-mediated degradation of both surrogates occurs	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nitrophenyl isopropyl methylphosphonate + H2O	a series of substituted phenoxyalkyl pyridinium oximes enhance the degradation of surrogates of sarin (i.e. nitrophenyl isopropyl methylphosphonate, NIMP) and VX (i.e. nitrophenyl ethyl methylphosphonate, NEMP). Neither NIMP nor NEMP is hydrolyzed effectively by paraoxonase PON1 if one of these oximes is absent. In the presence of eight novel oximes, PON1-mediated degradation of both surrogates occurs	Homo sapiens	nitrophenol + propan-2-yl hydrogen methylphosphonate	-	?

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Release 2023.1 (January 2023)