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Literature summary for 3.1.8.1 extracted from

  • Valiyaveettil, M.; Alamneh, Y.; Biggemann, L.; Soojhawon, I.; Doctor, B.P.; Nambiar, M.P.
    Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1 (2010), Biochem. Biophys. Res. Commun., 403, 97-102.
    View publication on PubMed
Search for more literature for 3.1.8.1

Application

Application Comment Organism
medicine PON1 shows potential as a prophylactic treatment against tabun exposure Homo sapiens
medicine PON1 shows potential as a prophylactic treatment against tabun exposure Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Trichoplusia ni larvae Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyquinoline specific paraoxonase 1 inhibitor, dose-dependent inhibition Homo sapiens
2-hydroxyquinoline specific paraoxonase 1 inhibitor, dose-dependent inhibition Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose column chromatography, Concanavalin A-Sepharose column chromatography, and Sepharose CL-6B gel filtration Homo sapiens
DEAE-Sepharose column chromatography, Concanavalin A-Sepharose column chromatography, and Sepharose CL-6B gel filtration Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-
serum
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diisopropyl fluorophosphate + H2O
-
 Homo sapiens ?
-
 ?
diisopropyl fluorophosphate + H2O
-
 Oryctolagus cuniculus ?
-
 ?
sarin + H2O efficient hydrolysis of sarin (11 nM) is observed with about 0.08-0.25 units of paraoxonase 1 Homo sapiens ?
-
 ?
sarin + H2O efficient hydrolysis of sarin (11 nM) is observed with about 0.08-0.25 units of paraoxonase 1 Oryctolagus cuniculus ?
-
 ?
soman + H2O efficient hydrolysis of soman (3 nM) is observed with about 0.08-0.25 units of paraoxonase 1 Homo sapiens ?
-
 ?
soman + H2O efficient hydrolysis of soman (3 nM) is observed with about 0.08-0.25 units of paraoxonase 1 Oryctolagus cuniculus ?
-
 ?
tabun + H2O efficient hydrolysis of tabun (100 nM) is observed with about 0.025-0.04 units of paraoxonase 1. Tabun hydrolysis with paraoxonase 1 is about 30-60times and about 200-260times more efficient than that with sarin and soman, respectively Homo sapiens ?
-
 ?
tabun + H2O efficient hydrolysis of tabun (100 nM) is observed with about 0.025-0.04 units of paraoxonase 1. Tabun hydrolysis with paraoxonase 1 is about 30-60times and about 200-260times more efficient than that with sarin and soman, respectively Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 40000-45000, paraoxonase 1 is separated as three bands with an approximate molecular weight of 40000-45000 Da, SDS-PAGE Homo sapiens
? x * 40000-45000, paraoxonase 1 is separated as three bands with an approximate molecular weight of 40000-45000 Da, SDS-PAGE Oryctolagus cuniculus

General Information

General Information Comment Organism
physiological function paraoxonase 1 functions as an efficient catalytic bioscavenger against nerve agents Homo sapiens
physiological function paraoxonase 1 functions as an efficient catalytic bioscavenger against nerve agents Oryctolagus cuniculus