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Literature summary for 3.1.8.1 extracted from
- Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS (2008), Neurology, 70, 929-934.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Q192R | the mutation is associated with sporadic amyotrophic lateral sclerosis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diazoxon + H2O | highest activity with diazoxon | Homo sapiens | ? | - |
? |  |
| paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
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Release 2023.1 (January 2023)
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