Application | Comment | Organism |
---|---|---|
medicine | the RR-phenotype of Q192R with low PON1 activity towards paraoxon and diazoxon is significantly more frequent in newly diagnosed diabetes type 2 subjects compared with normal glucose tolerance subjects | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Q192R | the homozygote phenotype has significant lower PON1 activity towards paraoxon and diazoxon than the wild type enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diazoxon + H2O | the homozygote wild type enzyme (QQ phenotype of Q192R) hydrolyzes diaxozon more rapidly than paraoxon | Homo sapiens | 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate | - |
? | |
paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase 1 | - |
Homo sapiens |
PON1 | - |
Homo sapiens |