Application | Comment | Organism |
---|---|---|
additional information | PON1 is an attractive as a candidate bioscavenger of organophosphorus compounds | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | residues Phe222 and His115 are important in organophosphorus substrate specificity and catalysis | Homo sapiens | ? | - |
? | |
O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate + H2O | i.e. VX, a highly toxic organophosphorus nerve agent, stereospecific hydrolysis | Homo sapiens | ? | - |
? | |
sarin + H2O | a highly toxic organophosphorus nerve agent, stereospecific hydrolysis | Homo sapiens | methylphosphonofluoride acid + ? | - |
? | |
soman + H2O | i.e. pinacolyl methylphosphonofluoridate, a highly toxic organophosphorus nerve agent, stereospecific hydrolysis | Homo sapiens | methylphosphonofluoride acid + 3,3-dimethylbutan-2-ol | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PON1 is a six-fold beta-propeller enzyme | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase 1 | - |
Homo sapiens |
PON1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |