Application | Comment | Organism |
---|---|---|
additional information | design of stable mutants on PON1-scavengers to be used as safe and effective countermeasures to challenge organophosphates | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type PON1 and PON1-human phosphate-binding protein hybrid in Escherichia coli | Homo sapiens |
General Stability | Organism |
---|---|
human phosphate-binding protein stabilizes the enzyme and its conformations | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lipid particle | the enzyme is associated to HDL and human phosphate-binding protein | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PON1 has a protective role e.g. against organophosphorous poisoning, but also against vascular diseases, PON1 has an anti-atherogenic activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
human phosphate-binding protein increases the storage stability of PON1 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PON1 has a protective role e.g. against organophosphorous poisoning, but also against vascular diseases, PON1 has an anti-atherogenic activity | Homo sapiens | ? | - |
? | |
additional information | PON1 is associated to HDL and human phosphate-binding protein | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase | - |
Homo sapiens |
paraoxonase-1 | - |
Homo sapiens |
PON1 | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
PON1 is highly thermostable, especially when associated to the human phosphate-binding protein | Homo sapiens |