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Literature summary for 3.1.8.1 extracted from

  • Kuo, C.L.; La Du, B.N.
    Comparison of purified human and rabbit serum paraoxonases (1995), Drug Metab. Dispos., 23, 935-944.
    View publication on PubMed
Search for more literature for 3.1.8.1

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites Homo sapiens
Ca2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites Oryctolagus cuniculus
Cd2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Homo sapiens
Cd2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Oryctolagus cuniculus
Zn2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Homo sapiens
Zn2+ Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE Oryctolagus cuniculus
40600
-
 human serum contains one major species of PON monomer (44300 Da) and a minor species of PON monomer (40600 kDa) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein at least 2 N-linked sugar chains, contains sialic acid residues Homo sapiens
glycoprotein at least 2 N-linked sugar chains, contains sialic acid residues Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Oryctolagus cuniculus
-
blood serum contains A-type paraoxonase and B-type paraoxonase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paraoxon + H2O 0.2% of the activity with phenyl acetate Oryctolagus cuniculus diethylphosphate + 4-nitrophenol
-
 ?
paraoxon + H2O A-type paraoxonase shows 0.06% of the activity with phenyl acetate, B-type paraoxonase shows 2.5% of the activity with phenyl acetate Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?