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Literature summary for 3.1.8.1 extracted from

  • Ng, C.J.; Wadleigh, D.J.; Gangopadhyay, A.; Hama, S.; Grijalva, V.R.; Navab, M.; Fogelman, A.M.; Reddy, S.T.
    Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein (2001), J. Biol. Chem., 276, 44444-44449.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in HeLa cells, expression as GST-fusion protein in Escherichia coli BL21 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme pON2 is not associated with HDL or LDL Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
x * 44000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isozyme PON2 has antioxidant properties, prevents low density lipoprotein lipid peroxidation and reverses the oxidation of mildly oxidized low density lipoproteins ?
-
?
additional information Homo sapiens the enzyme PON2 has antioxidant properties, prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of mildly oxidized LDL to induce monocyte chemotaxis ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme PON2
-
Homo sapiens
-
paraoxonase PON2
-

Source Tissue

Source Tissue Comment Organism Textmining
arterial smooth muscle cell
-
Homo sapiens
-
artery wall
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozyme PON2 has antioxidant properties, prevents low density lipoprotein lipid peroxidation and reverses the oxidation of mildly oxidized low density lipoproteins Homo sapiens ?
-
?
additional information the enzyme PON2 has antioxidant properties, prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of mildly oxidized LDL to induce monocyte chemotaxis Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 44000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
More also EC 3.1.8.1 Homo sapiens
paraoxonase-2
-
Homo sapiens
PON2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens